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2015-11-05

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cc-by (c) Sureda-Gómez, M. et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/115971

Posterior Wnts have distinct roles in specification and patterning of the planarian posterior region

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https://doi.org/10.3390/ijms161125970

Abstract

The wnt signaling pathway is an intercellular communication mechanism essential in cell-fate specification, tissue patterning and regional-identity specification. A βcatenin-dependent signal specifies the AP (Anteroposterior) axis of planarians, both during regeneration of new tissues and during normal homeostasis. Accordingly, four wnts (posterior wnts) are expressed in a nested manner in central and posterior regions of planarians. We have analyzed the specific role of each posterior wnt and the possible cooperation between them in specifying and patterning planarian central and posterior regions. We show that each posterior wnt exerts a distinct role during re-specification and maintenance of the central and posterior planarian regions, and that the integration of the different wnt signals (βcatenin dependent and independent) underlies the patterning of the AP axis from the central region to the tip of the tail. Based on these findings and data from the literature, we propose a model for patterning the planarian AP axis.

Subject

Planària (Gènere), Transducció de senyal cel·lular, Proteïnes

Subject (English)

Planaria (Genus), Cellular signal transduction, Proteins

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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SUREDA GÓMEZ, Miquel, PASCUAL CARRERAS, Eudald and ADELL I CREIXELL, Teresa. Posterior Wnts have distinct roles in specification and patterning of the planarian posterior region. International Journal of Molecular Sciences. 2015. Vol. 16, num. 11, pags. 26543-26554. ISSN 1422-0067. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/115971

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