Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/115971
Posterior Wnts have distinct roles in specification and patterning of the planarian posterior region
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The wnt signaling pathway is an intercellular communication mechanism essential in cell-fate specification, tissue patterning and regional-identity specification. A βcatenin-dependent signal specifies the AP (Anteroposterior) axis of planarians, both during regeneration of new tissues and during normal homeostasis. Accordingly, four wnts (posterior wnts) are expressed in a nested manner in central and posterior regions of planarians. We have analyzed the specific role of each posterior wnt and the possible cooperation between them in specifying and patterning planarian central and posterior regions. We show that each posterior wnt exerts a distinct role during re-specification and maintenance of the central and posterior planarian regions, and that the integration of the different wnt signals (βcatenin dependent and independent) underlies the patterning of the AP axis from the central region to the tip of the tail. Based on these findings and data from the literature, we propose a model for patterning the planarian AP axis.
Matèries (anglès)
Citació
Citació
SUREDA GÓMEZ, Miquel, PASCUAL CARRERAS, Eudald and ADELL I CREIXELL, Teresa. Posterior Wnts have distinct roles in specification and patterning of the planarian posterior region. International Journal of Molecular Sciences. 2015. Vol. 16, num. 11, pags. 26543-26554. ISSN 1422-0067. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/115971