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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/162326
The buckwheat iminosugar d-fagomine attenuates sucrose-induced steatosis and hypertension in rats
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Scope: This study examines the long-term functional effects of D-fagomine on sucrose4 induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods & results: Wistar Kyoto (WKY) rats were fed a 35% sucrose solution with D- fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. We recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. D-Fagomine reduced sucrose-induced hypertension, urine uric acid and F2-IsoPs (markers of oxidative stress; OS), steatosis and liver DAGs, without significantly affecting perigonadal fat deposition and impaired glucose tolerance. It also promoted excretion of enterobacteriales generated by the dietary intervention. Conclusion: D-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
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RAMOS ROMERO, Sara, HEREU, Mercè, ATIENZA, Lidia, AMÉZQUETA, Susana, CASAS, Josefina, MUÑOZ, Silvia, MEDINA, Isabel, MIRALLES-PÉREZ, Bernat, ROMEU FERRAN, Marta, TORRES, Josep lluís. The buckwheat iminosugar d-fagomine attenuates sucrose-induced steatosis and hypertension in rats. _Molecular Nutrition & Food Research_. 2019. Vol. 64, núm. 1, pàgs. 1900564-1900564. [consulta: 24 de gener de 2026]. ISSN: 1613-4125. [Disponible a: https://hdl.handle.net/2445/162326]