Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

659330.pdf (572.23 KB)

Document type

Article

Version

Accepted version

Publication date

2016-04-15

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/99052

Enantioselective total synthesis of fluvirucinin B1

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://dx.doi.org/10.1021/acs.orglett.6b00513

Abstract

A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed.

Subject

Síntesi orgànica, Lactames

Subject (English)

Organic synthesis, Lactams

Citation

Collections

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citation

GUIGNARD, Guillaume Michel Pablo, et al. Enantioselective total synthesis of fluvirucinin B1. Organic Letters. 2016. Vol. 18, num. 81, pags. 1788-1791. ISSN 1523-7060. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/99052

Export metadata

JSON - METS

Share record