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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/138499
Novel cyclometallated iridium catalysts for asymmetric hydrogenation of N-methyl and N-phenyl imines
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In this work, three acetophenone N-phenyl imine derivatives functionalized in the para position have been prepared and cyclometallated to Ir-MaxPHOX catalyst. One of the additives has a hydrogen bond acceptor group, while the others have bulky substituents. The behavior of these compounds in asymmetric hydrogenation of acetophenone N-methyl and N-phenyl imine substrates has been studied. The additive containing a hydrogen bond acceptor provided better enantioselectivity than the others. This reinforces the hypothesis that a hydrogen bond interaction between the catalyst and the substrate would increase the selectivity. Additives with bulky substituents provided worse results, probably due to steric hindrance, decreasing the selectivity
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Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2019, Tutors: Xavier Verdaguer Espaulella, Ernest Salomó i Prat, Josep Mª Rojo Solé
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FERNÁNDEZ SABATÉ, Marc. Novel cyclometallated iridium catalysts for asymmetric hydrogenation of N-methyl and N-phenyl imines. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/138499