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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/122199
Plasmodium vivax and Plasmodium falciparum infection dynamics: re-infections, recrudescences and relapses
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BACKGROUND: In malaria endemic populations, complex patterns of
Plasmodium vivax and Plasmodium falciparum blood-stage infection
dynamics may be observed. Genotyping samples from longitudinal
cohort studies for merozoite surface protein (msp) variants
increases the information available in the data, allowing
multiple infecting parasite clones in a single individual to be
identified. msp genotyped samples from two longitudinal cohorts
in Papua New Guinea (PNG) and Thailand were analysed using a
statistical model where the times of acquisition and clearance
of each clone in every individual were estimated using a process
of data augmentation. RESULTS: For the populations analysed, the
duration of blood-stage P. falciparum infection was estimated as
36 (95% Credible Interval (CrI): 29, 44) days in PNG, and 135
(95% CrI 94, 191) days in Thailand. Experiments on simulated
data indicated that it was not possible to accurately estimate
the duration of blood-stage P. vivax infections due to the lack
of identifiability between a single blood-stage infection and
multiple, sequential blood-stage infections caused by relapses.
Despite this limitation, the method and data point towards short
duration of blood-stage P. vivax infection with a lower bound of
24 days in PNG, and 29 days in Thailand. On an individual level,
P. vivax recurrences cannot be definitively classified into
re-infections, recrudescences or relapses, but a probabilistic
relapse phenotype can be assigned to each P. vivax sample,
allowing investigation of the association between
epidemiological covariates and the incidence of relapses.
CONCLUSION: The statistical model developed here provides a
useful new tool for in-depth analysis of malaria data from
longitudinal cohort studies, and future application to data sets
with multi-locus genotyping will allow more detailed
investigation of infection dynamics.
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WHITE, Michael t., KARL, Stephan, KOEPFLI, Cristian, LONGLEY, Rhea j., HOFMANN, Natalie e., WAMPFLER, Rahel, FELGER, Ingrid, SMITH, Thomas, NGUITRAGOOL, Wang, SATTABONGKOT, Jetsumon, ROBINSON, Leanne j., GHANI, Azra c., MUELLER, Ivo. Plasmodium vivax and Plasmodium falciparum infection dynamics:
re-infections, recrudescences and relapses. _Malaria Journal_. 2018. Vol. 17, núm. 170. [consulta: 27 de gener de 2026]. ISSN: 1475-2875. [Disponible a: https://hdl.handle.net/2445/122199]