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2012-05-16

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/58597

Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

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Recurs relacionat

http://dx.doi.org/10.3892/ol.2012.718

Resum

Voltage-dependent K+ channels (Kv) are involved in the proliferation and differentiation of mammalian cells, since Kv antagonists impair cell cycle progression. Although myofibers are terminally differentiated, some myoblasts may re-enter the cell cycle and proliferate. Since Kv1.3 and Kv1.5 expression is remodeled during tumorigenesis and is involved in smooth muscle proliferation, the purpose of this study was to analyze the expression of Kv1.3 and Kv1.5 in smooth muscle neoplasms. In the present study, we examined human samples of smooth muscle tumors together with healthy speci­mens. Thus, leiomyoma (LM) and leiomyosarcoma (LMS) tumors were analyzed. Results showed that Kv1.3 was poorly expressed in the healthy muscle and indolent LM specimens, whereas aggressive LMS showed high levels of Kv1.3 expression. Kv1.5 staining was correlated with malignancy. The findings show a remodeling of Kv1.3 and Kv1.5 in human smooth muscle sarcoma. A correlation of Kv1.3 and Kv1.5 expression with tumor aggressiveness was observed. Thus, our results indicate Kv1.5 and Kv1.3 as potential tumorigenic targets for aggressive human LMS.

Matèries

Leucòcits, Càncer, Macròfags, Fisiologia cel·lular, Canals de potassi

Matèries (anglès)

Leucocytes, Cancer, Macrophages, Cell physiology, Potassium channels

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Col·leccions

Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

BIELANSKA, Joanna, HERNÁNDEZ-LOSA, Javier, MOLINE, Terersa, SOMOZA, Rosa, RAMÓN Y CAJAL AGÜERAS, Santiago, CONDOM I MUNDÓ, Enric, FERRERES, Joan c., FELIPE CAMPO, Antonio. Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness. _Oncology Letters_. 2012. Vol. 4, núm. 227-230. [consulta: 28 de gener de 2026]. ISSN: 1792-1074. [Disponible a: https://hdl.handle.net/2445/58597]

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