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Accepted version

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2022-08-23

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/220243

Mesoporous Silica particles are phagocytosed by microglia and induce a mild inflammatory response in vitro.

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https://doi.org/10.2217/nnm-2022-0026

Abstract

Aim: Mesoporous silica particles (MSPs) are broadly used drug delivery carriers. In this study, the authors analyzed the responses to MSPs of astrocytes and microglia, the two main cellular players in neuroinflammation. Materials & methods: Primary murine cortical mixed glial cultures were treated with rhodamine B-labeled MSPs. Results: MSPs are avidly internalized by microglial cells and remain inside the cells for at least 14 days. Despite this, MSPs do not affect glial cell viability or morphology, basal metabolic activity or oxidative stress. MSPs also do not affect mRNA levels of key proinflammatory genes; however, in combination with lipopolysaccharide, they significantly increase extracellular IL-1β levels. Conclusion: These results suggest that MSPs could be novel tools for specific drug delivery to microglial cells.

Subject

Astròcits, Partícules (Matèria), Sílice, Inflamació, Micròglia, Circuit neuronal

Subject (English)

Astrocytes, Particles, Silica, Inflammation, Microglia, Neural circuitry

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Articles publicats en revistes (Ciències Fisiològiques)

Citation

SALA JARQUE, Julia, et al. Mesoporous Silica particles are phagocytosed by microglia and induce a mild inflammatory response in vitro. Nanomedicine. 2022. Vol. 17, num. 15, pags. 1077-1094. ISSN 1743-5889. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/220243

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