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TFM_Gómez_García_Sarah.pdf (9.55 MB)

Tipus de document

Treball de fi de màster

Data de publicació

2025-06

Llicència de publicació

cc-by-nc-nd (c) Gómez García, Sarah, 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/229785

Impact of autistic-derived metabolites on the dynamics and connectivity of neuronal cultures

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Autism spectrum disorder (ASD) is a neurodevelopmental condition with complex and largely unknown causes. While genetic factors are widely studied, growing evidence suggests that environmental influences, including gut microbiome alterations, may play a significant role in ASD pathophysiology. Recent hypotheses propose that disruptions in gut microbiota composition could impact brain function and contribute to the development of ASD. This study investigates the effects of ASD-associated microbiota metabolites on the dynamics and connectivity of neuronal cultures, which provide an accessible model to explore brain-like processes at the cellular level, offering insights into how neuronal abnormalities may lead to dysfunction and disease. To examine this, three types of cultures are analyzed: cultures treated with fecal-derived metabolites from individuals with ASD or neurotypical individuals, and control cultures. All samples contain metabolites that differentially influence neuronal behavior. Experimental data is combined with an in silico model to help understanding the relationship between neuron-level connectivity and network-wide collective behavior. Results show that ASD cultures exhibit alterations in spontaneous activity and effective connectivity as compared to the neurotypical condition, although these alterations are not preserved along development, an aspect that hints at the activation of plasticity mechanisms that counterbalance possible damage By elucidating the effects of ASD-associated microbiota metabolites on neuronal function, this study helps advance our understanding of gut-brain interactions in ASD and their role in neurodevelopmental disorders

Descripció

Treballs Finals de Màster en Física dels Sistemes Complexos i Biofísica, Facultat de Física, Universitat de Barcelona. Curs: 2024-2025. Tutor: Jordi Soriano Fradera

Matèries

Xarxes neuronals (Neurobiologia), Metabòlits, Autisme, Treballs de fi de màster

Matèries (anglès)

Neural networks (Neurobiology), Metabolites, Autism, Master's thesis

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Màster Oficial - Física dels Sistemes Complexos i Biofísica

Citació

GÓMEZ GARCÍA, Sarah. Impact of autistic-derived metabolites on the dynamics and connectivity of neuronal cultures. [consulted: 5 of August of 2026]. Available at: https://hdl.handle.net/2445/229785

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