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2014-06-03

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cc-by (c) Martínez-Clemente, José et al., 2014
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/56203

Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.

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Recurs relacionat

http://dx.doi.org/10.1371/journal.pone.0099002

Resum

Mephedrone is a drug of abuse marketed as 'bath salts'. There are discrepancies concerning its long-term effects. We have investigated the neurotoxicity of mephedrone in mice following different exposition schedules. Schedule 1: four doses of 50 mg/kg. Schedule 2: four doses of 25 mg/kg. Schedule 3: three daily doses of 25 mg/kg, for two consecutive days. All schedules induced, in some animals, an aggressive behavior and hyperthermia as well as a decrease in weight gain. Mephedrone (schedule 1) induced dopaminergic and serotoninergic neurotoxicity that persisted 7 days after exposition. At a lower dose (schedule 2) only a transient dopaminergic injury was found. In the weekend consumption pattern (schedule 3), mephedrone induced dopamine and serotonin transporter loss that was accompanied by a decrease in tyrosine hydroxylase and tryptophan hydroxylase 2 expression one week after exposition. Also, mephedrone induced a depressive-like behavior, as well as a reduction in striatal D2 density, suggesting higher susceptibility to addictive drugs. In cultured cortical neurons, mephedrone induced a concentration-dependent cytotoxic effect. Using repeated doses for 2 days in an elevated ambient temperature we evidenced a loss of frontal cortex dopaminergic and hippocampal serotoninergic neuronal markers that suggest injuries at nerve endings.

Matèries

Amfetamines, Lòbul frontal, Neurotoxicologia, Ratolins (Animals de laboratori), Sistema nerviós central

Matèries (anglès)

Amphetamines, Frontal lobe, Neurotoxicology, Mice (Laboratory animals), Central nervous system

Citació

Col·leccions

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citació

MARTÍNEZ-CLEMENTE, José, et al. Dose and time-dependent selective neurotoxicity induced by mephedrone in mice. PLoS One. 2014. Vol. 9, num. 6, pags. e99002. ISSN 1932-6203. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/56203

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