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2015-05-14

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cc-by (c) Yáñez-Mó, María et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/169354

Biological properties of extracellular vesicles and their physiological functions

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Recurs relacionat

https://doi.org/10.3402/jev.v4.27066

Resum

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

Matèries

Vesícules seminals, Fisiologia, Espai extracel·lular

Matèries (anglès)

Seminal vesicles, Physiology, Extracellular space

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)

Citació

YÁÑEZ-MÓ, María, SILJANDER, Pia r.m., ANDREU, Zoraida, BEDINA ZAVEC, Apolonija, BORRÀS, Francesc e., BUZAS, Edit i., BUZAS, Krisztina, CASAL, Enriqueta, CAPPELLO, Francesco, CARVALHO, Joana, COLÁS, Eva, CORDEIRO-DA-SILVA, Anabela, FAIS, Stefano, FALCON PEREZ, Juan manuel, GHOBRIAL, Irene m., GIEBEL, Bernd, GIMONA, Mario, GRANER, Michael, GURSEL, Ihsan, GURSEL, Mayda, HEEGAARD, Niels h. h., HENDRIX, An, KIERULF, Peter, KOKUBUN, Katsutoshi, KOSANOVIĆ, Maja m., KRALJ-IGLIC, Veronika, KRÄMER-ALBERS, Eva-maria, LAITINEN, Saara, LÄSSER, Cecilia, LENER, Thomas, LIGETI, Erzsébet, OLIVEIRA, Carla, PÁLLINGER, Éva, LIPPS, Georg, LLORENTE, Alicia, LÖTVALL, Jan, PORTILLO OBANDO, Hernando a. del, RIGAU, Marina, OLIVAN RIERA, Mireia, REVENTÓS PUIGJANER, Jaume. Biological properties of extracellular vesicles and their physiological functions. _Journal Of Extracellular Vesicles_. 2015. Vol. 4, núm. 27066. [consulta: 23 de gener de 2026]. ISSN: 2001-3078. [Disponible a: https://hdl.handle.net/2445/169354]

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