Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/182331
Reduced cue-induced reinstatement of cocaine seeking behavior in Plcb1+/- mice
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Cocaine addiction causes serious health problems, and no effective treatment is available yet. We previously identified a genetic risk variant for cocaine addiction in the PLCB1 gene and found this gene upregulated in postmortem brains of cocaine abusers and in human dopaminergic neuron-like cells after an acute cocaine exposure. Here, we functionally tested the contribution of the PLCB1 gene to cocaine addictive properties using Plcb1+/- mice. First, we performed a general phenotypic characterization and found that Plcb1+/- mice showed normal behavior, although they had increased anxiety and impaired short-term memory. Subsequently, mice were trained for operant conditioning, self-administered cocaine for 10 days, and were tested for cocaine motivation. After extinction, we found a reduction in the cue-induced reinstatement of cocaine-seeking behavior in Plcb1+/- mice. After reinstatement, we identified transcriptomic alterations in the medial prefrontal cortex of Plcb1+/- mice, mostly related to pathways relevant to addiction like the dopaminergic synapse and long-term potentiation. To conclude, we found that heterozygous deletion of the Plcb1 gene decreases cue-induced reinstatement of cocaine-seeking, pointing at PLCB1 as a possible therapeutic target for preventing relapse and treating cocaine addiction.
Matèries
Matèries (anglès)
Citació
Citació
CABANA DOMÍNGUEZ, Judit, MARTÍN-GARCÍA, Elena, GALLEGO-ROMAN, Ana, MALDONADO, Rafael, FERNÀNDEZ CASTILLO, Noèlia, CORMAND RIFÀ, Bru. Reduced cue-induced reinstatement of cocaine seeking behavior in Plcb1+/- mice. _Translational Psychiatry_. 2021. Vol. 11, núm. 1, pàgs. 521. [consulta: 25 de febrer de 2026]. ISSN: 2158-3188. [Disponible a: https://hdl.handle.net/2445/182331]