Miniatura

Fitxers

651150.pdf (3.56 MB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2015-03-27

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/128141

Control of cell-cell forces and collective cell dynamics by the intercellular adhesome

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/ncb3135

Resum

Dynamics of epithelial tissues determine key processes in development, tissue healing and cancer invasion. These processes are critically influenced by cell-cell adhesion forces. However, the identity of the proteins that resist and transmit forces at cell-cell junctions remains unclear, and how these proteins control tissue dynamics is largely unknown. Here we provide a systematic study of the interplay between cell-cell adhesion proteins, intercellular forces and epithelial tissue dynamics. We show that collective cellular responses to selective perturbations of the intercellular adhesome conform to three mechanical phenotypes. These phenotypes are controlled by different molecular modules and characterized by distinct relationships between cellular kinematics and intercellular forces. We show that these forces and their rates can be predicted by the concentrations of cadherins and catenins. Unexpectedly, we identified different mechanical roles for P-cadherin and E-cadherin; whereas P-cadherin predicts levels of intercellular force, E-cadherin predicts the rate at which intercellular force builds up.

Matèries

Cèl·lules epitelials, Càncer

Matèries (anglès)

Epithelial cells, Cancer

Citació

Col·leccions

Articles publicats en revistes (Biomedicina)

Citació

BAZELLIÈRES, Elsa, CONTE, Vito, ELOSEGUI ARTOLA, Alberto, SERRA PICAMAL, Xavier, BINTANEL MORCILLO, María, ROCA-CUSACHS SOULERE, Pere, MUÑOZ, José j., SALES I PARDO, Marta, GUIMERÀ MANRIQUE, Roger, TREPAT GUIXER, Xavier. Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. _Nature Cell Biology_. 2015. Vol. 17, núm. 4, pàgs. 409-420. [consulta: 5 de febrer de 2026]. ISSN: 1465-7392. [Disponible a: https://hdl.handle.net/2445/128141]

Exportar metadades

JSON - METS

Compartir registre