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2012-09-12

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/56344

Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.

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http://dx.doi.org/10.1515/cclm-2012-0452

Abstract

Background: Hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) gene mutation have been postulated as a possible cause of recurrent miscarriage (RM). There is a wide variation in the prevalence of MTHFR polymorphisms and homocysteine (Hcy) plasma levels among populations around the world. The present study was undertaken to investigate the possible association between hyperhomocysteinemia and its causative genetic or acquired factors and RM in Catalonia, a Mediterranean region in Spain. Methods: Sixty consecutive patients with ≥ 3 unexplained RM and 30 healthy control women having at least one child but no previous miscarriage were included. Plasma Hcy levels, MTHFR gene mutation, red blood cell (RBC) folate and vitamin B12 serum levels were measured in all subjects. Results: No significant differences were observed neither in plasma Hcy levels, RBC folate and vitamin B12 serum levels nor in the prevalence of homozygous and heterozygous MTHFR gene mutation between the two groups studied. Conclusions: In the present study RM is not associated with hyperhomocysteinemia, and/or the MTHFR gene mutation.

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Aminoàcids, Vitamines B, Avortament, Genètica mèdica, Catalunya

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Amino acids, Vitamin B complex, Abortion, Medical genetics, Catalonia

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Articles publicats en revistes (Fonaments Clínics)

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CREUS FERRÉ, Montserrat, et al. Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain. Clinical Chemistry and Laboratory Medicine. 2012. Vol. 51, num. 3, pags. 693-699. ISSN 1434-6621. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/56344

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