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Published version

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2020-04-23

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cc-by (c) Domènech, Elena B. et al., 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/196081

The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies

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https://doi.org/10.3390/antiox9040347

Abstract

Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell homeostasis and elicits a protective cell response, which is most relevant in photoreceptors and retinal ganglion cells, neurons with a high metabolic rate that are continuously subject to light/oxidative stress insults. We analyze how the alteration of cellular endogenous pathways for protection against oxidative stress leads to retinal dysfunction in prevalent (age-related macular degeneration, glaucoma) as well as in rare genetic visual disorders (Retinitis pigmentosa, Leber hereditary optic neuropathy). We also highlight some of the key molecular actors and discuss potential therapies using antioxidants agents, modulators of gene expression and inducers of cytoprotective signaling pathways to treat damaging oxidative stress effects and ameliorate severe phenotypic symptoms in multifactorial and rare retinal dystrophies.

Subject

Estrès oxidatiu, Fotoreceptors, Retina, Glaucoma

Subject (English)

Oxidative stress, Photoreceptors, Retina, Glaucoma

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citation

DOMÈNECH, Elena B. and MARFANY I NADAL, Gemma. The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies. Antioxidants. 2020. Vol. 9, num. 4. ISSN 2076-3921. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/196081

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