Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

657945.pdf (12.1 MB)

Document type

Article

Version

Published version

Publication date

2015-08-31

Publication license

cc-by (c) Lagunas, Anna et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/121073

Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.3389/fbioe.2015.00132

Abstract

Chemical gradient surfaces are described as surfaces with a gradually varying composition along their length. Continuous chemical gradients have recently been proposed as an alternative to discrete microarrays for the high-throughput screening of the effects of ligand concentration in cells. Here, we review some of the most recent examples in which gradients have been used to evaluate the effect of a varying ligand concentration in cell adhesion, morphology, growth, and differentiation of cells, including some of our recent findings. They show the importance of the organization of ligands at the nanoscale, which is highlighted by abrupt changes in cell behavior at critical concentration thresholds.

Subject

Diferenciació cel·lular, Morfologia (Biologia)

Subject (English)

Cell diferentiation, Morphology (Biology)

Citation

Collections

Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Publicacions de projectes de recerca finançats per la UE

Citation

LAGUNAS, Anna, MARTÍNEZ FRAIZ, Elena and SAMITIER I MARTÍ, Josep. Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses. Frontiers in Bioengineering and Biotechnology. 2015. Vol. 3, num. 132. ISSN 2296-4185. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/121073

Export metadata

JSON - METS

Share record