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Self-organization and cooperativity of weakly coupled molecular motors under unequal loading
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We study the collective dynamics of Brownian motors moving on a one-dimensional track when an external load is applied to the leading motor. Motors are driven by a two-state ratchet mechanism, which is appropriate to single-headed kinesins, and their relative motion is only constrained by their mutual interaction potential (weak coupling). We show that unequal loading enhances cooperativity, leading to the formation of clusters with velocities and efficiencies higher than those predicted by simple superposition. When a weak attraction between motors is present, we find nonmonotonic collective velocity-force curves, hysteretic phenomena, and a dynamic self-regulation mechanism that selects the cluster size for optimal performance.
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BRUGUÉS, Jan and CASADEMUNT I VIADER, Jaume. Self-organization and cooperativity of weakly coupled molecular motors under unequal loading. Physical Review Letters. 2009. Vol. 102, num. 11, pags. 118104. ISSN 0031-9007. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/140068