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2012-10-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/167783

The EMT signaling pathways in endometrial carcinoma

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Recurs relacionat

https://doi.org/10.1007/s12094-012-0866-3

Resum

Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic factors. For this process to occur, epithelial tumor cells need to undergo an epithelial to mesenchymal transition (EMT), either transiently or stably, and to differing degrees. This process has been extensively described in other types of cancer but has been poorly studied in EC. In this review, several features of EMT and the main molecular pathways responsible for triggering this process are investigated in relation to EC. The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Pathways including progesterone receptor, TGFβ, ETV5 and microRNAs are deeply related to the EMT process in EC.

Matèries

Càncer d'endometri, Càncer, Epiteli, Genètica

Matèries (anglès)

Endometrial cancer, Cancer, Epithelium, Genetics

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)

Citació

COLÁS, Eva, PEDROLA, Nuria, DEVIS, Laura, ERTEKIN, Tugçe, CAMPOY, Irene, MARTÍNEZ SÁEZ, Elena, LLAURADÓ, Marta, RIGAU, Marina, OLIVAN RIERA, Mireia, GARCIA, Marta, CABRERA, Sílvia, GIL MORENO, Antonio, XERCAVINS, Jordi, CASTELLVÍ, Josep, GARCIA, Angel, RAMÓN Y CAJAL AGÜERAS, Santiago, MORENO-BUENO, Gema, DOLCET, Xavier, ALAMEDA, Francesc, PALACIOS, José, PRAT, Jaime, DOLL, Andreas, MATIAS-GUIU, Xavier, ABAL POSADA, Miguel, REVENTÓS PUIGJANER, Jaume. The EMT signaling pathways in endometrial carcinoma. _Clinical & Translational Oncology_. 2012. Vol. 14, núm. 10, pàgs. 715-720. [consulta: 27 de gener de 2026]. ISSN: 1699-048X. [Disponible a: https://hdl.handle.net/2445/167783]

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