Miniatura

Fitxers

658051.pdf (2.77 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2016-03-07

Llicència de publicació

cc-by-nc-sa (c) Braasch, I. et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/110854

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/ng.3526

Resum

To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.

Matèries

Teleostis, Models animals en la investigació, Genomes

Matèries (anglès)

Teleostei, Animal models in research, Genomes

Citació

Col·leccions

Articles publicats en revistes (Genètica, Microbiologia i Estadística)
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

BRAASCH, Ingo, GEHRKE, Andrew r., SMITH, Jeramiah j., KAWASAKI, Kazuhiko, MANOUSAKI, Tereza, PASQUIER, Jeremy, AMORES, Angel, DESVIGNES, Thomas, BATZEL, Peter, CATCHEN, Julian m., BERLIN, Aaron m., CAMPBELL, Michael s., BARRELL, Daniel, MARTIN, Kyle j., MULLEY, John f., RAVI, Vydianathan, LEE, Alison p., NAKAMURA, Tetsuya, CHALOPIN, Domitille, FAN, Shaohua, WCISEL, Dustin, CAÑESTRO GARCÍA, Cristian, SYDES, Jason, BEAUDRY, Felix e., SUN, Yi, HERTEL, Jana, BEAM, Michael j., FASOLD, Mario, ISHIYAMA, Mikio, JOHNSON, Jeremy, KEHR, Steffi, LARA, Marcia, LETAW, John h., LITMAN, Gary w., LITMAN, Ronda t., MIKAMI, Masato, OTA, Tatsuya, SAHA, Nil ratan, WILLIAMS, Louise, STADLER, Peter f.. The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.. _Nature Genetics_. 2016. Vol. 48, núm. 427-437. [consulta: 24 de gener de 2026]. ISSN: 1061-4036. [Disponible a: https://hdl.handle.net/2445/110854]

Exportar metadades

JSON - METS

Compartir registre