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2016-06-14

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cc-by (c) Cordeiro, Anna et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/105205

PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma.

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Recurs relacionat

https://doi.org/10.18632/oncotarget.10015

Resum

PiwiRNAs, small non-coding RNAs processed by Piwi proteins, are involved in maintaining genome stability in germline cells. Recently, piwiRNA expression has been identified in some tumors. We have examined the potential reactivation of the Piwi/piwiRNA pathway in classical Hodgkin lymphoma (cHL). We found that Piwi proteins and three selected piwiRNAs, including piR-651, were expressed in cHL patients and cell lines, indicating that the Piwi/piwiRNA pathway is active in cHL. Interestingly, low levels of piR-651 were associated with lack of complete response to first-line treatment, as well as shorter disease-free and overall survival in a cohort of 94 cHL patients. At diagnosis, piR-651 was underexpressed in cHL serum samples compared to healthy controls, while after complete remission, piR-651 levels increased to levels similar to healthy controls. This is the first evidence that piwiRNAs are active in tumor and serum samples and impact prognosis in cHL.

Matèries

Malaltia de Hodgkin, Limfomes, Micro RNAs

Matèries (anglès)

Hodgkin's disease, Lymphomas, MicroRNAs

Citació

Col·leccions

Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

CORDEIRO SANTANACH, Anna, et al. PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma. Oncotarget. 2016. Vol. 7, num. 29, pags. 46002-46013. ISSN 1949-2553. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/105205

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