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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219680
The polygenic basis of relapse after a first episode of schizophrenia
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Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11-0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse.
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GONZÀLEZ SEGURA, Àlex, PROHENS COLL, Llucia, GASSÓ ASTORGA, Patricia, RODRÍGUEZ FERRET, Natalia, GARCÍA RIZO, Clemente, MORENO-IZCO, Lucía, ANDREU-BERNABEU, Álvaro, ZORRILLA, Iñaki, MANÉ SANTACANA, Anna, RODRIGUEZ JIMENEZ, Roberto, ROLDÁN BEJARANO, Alexandra, SARRÓ, Salvador, IBÁÑEZ, Ángela, USALL I RODIÉ, Judith, SÁIZ, Pilar a, CUESTA, Manuel j., PARELLADA, Mara, GONZÁLEZ-PINTO, Ana, BERROCOSO, Esther, BERNARDO ARROYO, Miquel, MAS HERRERO, Sergi, MEZQUIDA MATEOS, Gisela, ARBELO, Néstor, DE MATTEIS, Mario, GALVAÑ, Joaquin, DUQUE GUERRA, Alejandra, ARIAS I QUERALT, Laia, PÉREZ BACIGALUPE, María, GONZÁLEZ ORTEGA, Itxaso, TOLL PRIVAT, Alba, CASANOVAS MARTÍNEZ, Francesc, SANCHEZ PASTOR, Luis, VALTUEÑA, Mercedes, POMAROL-CLOTET, Edith, GARCÍA LEÓN, María ángeles, BUTJOSA MOLINES, Anna, RUBIO ABADAL, Elena, RIBEIRO, María, LÓPEZ-ILUNDAIN, Jose m., SAIZ RUIZ, Jerónimo, LEÓN-QUISMONDO, Luis, RIVERO, Olga, RUIZ, Pedro, SEGARRA ECHEVARRÍA, Rafael, GARCÍA-PORTILLA GONZÁLEZ, María paz. The polygenic basis of relapse after a first episode of schizophrenia. _European Neuropsychopharmacology_. 2023. Vol. 75, núm. 80-92. [consulta: 21 de gener de 2026]. ISSN: 0924-977X. [Disponible a: https://hdl.handle.net/2445/219680]