Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease

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dc.contributor.authorRodríguez Urgellés, Ened
dc.contributor.authorCasas Torremocha, Diana
dc.contributor.authorSancho Balsells, Anna
dc.contributor.authorBallasch, Ivan
dc.contributor.authorGarcía-García, Esther
dc.contributor.authorMiquel Rio, Lluís
dc.contributor.authorManasanch, Arnau
dc.contributor.authorDel Castillo, Ignacio
dc.contributor.authorChen, Wanqi
dc.contributor.authorPupak, Anika
dc.contributor.authorBrito, Verónica
dc.contributor.authorTornero, Daniel
dc.contributor.authorRodríguez Allué, Manuel José
dc.contributor.authorBortolozzi Biasoni, Analía
dc.contributor.authorSánchez-Vives, María Victoria
dc.contributor.authorGiralt Torroella, Albert
dc.contributor.authorAlberch i Vié, Jordi, 1959-
dc.date.accessioned2024-02-15T16:27:13Z
dc.date.issued2023-11-21
dc.date.updated2024-02-15T16:27:13Z
dc.description.abstractHere, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes.
dc.format.extent25 p.
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1007/s00018-023-05015-z
dc.identifier.idgrec741899
dc.identifier.issn1420-682X
dc.identifier.pmid37987826
dc.identifier.urihttps://hdl.handle.net/2445/207639
dc.language.isoeng
dc.publisherSpringer Verlag
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1007/s00018-023-05015-z
dc.relation.ispartofCellular and Molecular Life Sciences, 2023, vol. 80, num.12
dc.relation.urihttps://doi.org/10.1007/s00018-023-05015-z
dc.rightscc by (c) Rodríguez Urgellés, Ened et al., 2023
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Biomedicina)
dc.subject.classificationCorea de Huntington
dc.subject.classificationHipotàlem
dc.subject.classificationGanglis basals
dc.subject.classificationNeurones sensorials
dc.subject.classificationElectrofisiologia
dc.subject.otherHuntington's chorea
dc.subject.otherHypothalamus
dc.subject.otherBasal ganglia
dc.subject.otherSensory neurons
dc.subject.otherElectrophysiology
dc.titleThalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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