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Accepted version

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2016-06-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/106531

Neuron-microglia interactions in motor neuron degeneration. The inflammatory hypothesis in amyotrophic lateral sclerosis revisited.

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https://doi.org/10.2174/0929867324666161123091314

Abstract

Research into the pathogenesis of amyotrophic lateral sclerosis (ALS) has obtainedd notable gene discoveries, although, to date, only progress with regard to treatment has been very modest. Currently ALS is considered a multifactorial disease that presents diverse clinical presentations, ranging from a monogenic inherited disease to an autoimmune pathology, and develops with misfolded protein aggregation and neuroinflammation. An important factor related to ALS pathogenesis is the microglial activation associated with degenerative motor neurons. This activation leads to changes in the expression of a wide range of genes related to phagocytosis and inflammation, and to profound modifications in the dynamic interactions between neurons and glial cells. Overactivation and deregulation of microglial activity causes deleterious effects and leads to neuronal death. However, the involvement of microglia in non-inflammatory functions challenges our concept of neuroinflammation and opens up new possibilities for the study of the pathophysiological mechanisms of ALS. In this review we summarize the current knowledge on the adaptive interactions between neurons and microglia in ALS. We also discuss the hypothesis that controlling the extent of microglial activation and neuroinflammation may have clinical and therapeutic benefits for the condition.

Subject

Esclerosi lateral amiotròfica, Micròglia, Inflamació, Neurones motores, Malalties neurodegeneratives

Subject (English)

Amyotrophic lateral sclerosis, Microglia, Inflammation, Motor neurons, Neurodegenerative Diseases

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

RODRÍGUEZ ALLUÉ, Manuel José and MAHY GEHENNE, Josette Nicole. Neuron-microglia interactions in motor neuron degeneration. The inflammatory hypothesis in amyotrophic lateral sclerosis revisited. Current Medicinal Chemistry. 2016. Vol. 23, num. 42, pags. 4753-4772. ISSN 0929-8673. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/106531

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