Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/34480
The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Planarian flatworms are an exception among bilaterians in that they possess a large pool of adult stem cells that enables them to promptly regenerate any part of their body, including the brain. Although known for two centuries for their remarkable regenerative capabilities, planarians have only recently emerged as an attractive model for studying regeneration and stem cell biology. This revival is due in part to the availability of a sequenced genome and the development of new technologies, such as RNA interference and next-generation sequencing, which facilitate studies of planarian regeneration at the molecular level. Here, we highlight why planarians are an exciting tool in the study of regeneration and its underlying stem cell biology in vivo, and discuss the potential promises and current limitations of this model organism for stem cell research and regenerative medicine.
Subject (English)
Citation
Citation
GENTILE, L., CEBRIÀ SÁNCHEZ, Francesc and BARTSCHERER, Kerstin. The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration. Disease Models & Mechanisms. 2011. Vol. 4, num. 12-19. ISSN 1754-8403. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/34480