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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/216695
PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling
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Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are diffuse. Here, we show that 1,2-dioleoyl-sn-glycero-3-phos- pho-(1’-myo-inositol) [PI(18:1/18:1)] is a SCD1-derived signaling lipid, which inhibits p38 mitogen-activated protein kinase activation, counteracts UPR, endoplasmic reticulum- associated protein degradation, and apoptosis, regulates autophagy, and maintains cell morphology and proliferation. SCD1 expression and the cellular PI(18:1/18:1) proportion decrease during the onset of cell death, thereby repressing protein phosphatase 2 A and enhancing stress signaling. This counter-regulation applies to mechanistically diverse death- inducing conditions and is found in multiple human and mouse cell lines and tissues of Scd1- defective mice. PI(18:1/18:1) ratios reflect stress tolerance in tumorigenesis, chemoresistance, infection, high-fat diet, and immune aging. Together, PI(18:1/18:1) is a lipokine that links fatty acid unsaturation with stress responses, and its depletion evokes stress signaling.
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THÜRMER, Maria, et al. PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling. Nature Communications. 2022. Vol. 13, num. 1, pags. 1-21. ISSN 2041-1723. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/216695