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2014-12-29

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/64890

Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century

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The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer's disease patients. Expression in different tissues and the degree of sequence identity among mammals indicate an essential and non-tissue specific physiological function. APP is anchored to the membrane and displays a single C-terminal intracellular domain and a longer N-terminal extracellular domain. The basic biochemical properties and the scattered data on research, not related to production of beta-amyloid peptide, suggest that the protein and the molecules resulting from APP proteolytic cleavage may act as adhesion factors, enzymes, hormones/neurotransmitters and/or protease inhibitors. APP deserves to be known for its quite notable properties and its physiological role(s).

Matèries

Malaltia d'Alzheimer, Expressió gènica, Proteïnes de membrana

Matèries (anglès)

Alzheimer's disease, Gene expression, Membrane proteins

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

FRANCO FERNÁNDEZ, Rafael, et al. Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century. Journal of Neurology and Neurological Disorders. 2014. Vol. 1, num. 1, pags. 1-6. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/64890

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