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2021-02-03

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cc-by (c) Crispi Brillas, Fàtima et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/177006

Low birth weight as a potential risk factor for severe COVID-19 in adults

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https://doi.org/10.1038/s41598-021-82389-9

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The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2.500 g. Age (adjusted OR (aOR) 1.04 [1-1.07], P = 0.012), male sex (aOR 3.39 [1.72-6.67], P < 0.001), hypertension (aOR 3.37 [1.69-6.72], P = 0.001), and LBW (aOR 3.61 [1.55-8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74-0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms.

Matèries

COVID-19, Pes corporal

Matèries (anglès)

COVID-19, Body weight

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)

Citació

CRISPI BRILLAS, Fàtima, CROVETTO, Francesca, LARROYA, Marta, CAMACHO SÁEZ, Alba, TORTAJADA, Marta, SIBILA VIDAL, Oriol, BADIA, Joan ramon, LÓPEZ, Marta, VELLVÉ, Kilian, GARCÍA, Ferràn, TRILLA GARCÍA, Antoni, FANER, Rosa, BLANCO VICH, Isabel, BORRÀS, Roger, AGUSTÍ GARCÍA-NAVARRO, Àlvar, GRATACÓS SOLSONA, Eduard. Low birth weight as a potential risk factor for severe COVID-19 in adults. _Scientific Reports_. 2021. Vol. 11, núm. 1, pàgs. 2909. [consulta: 9 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/177006]

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