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2024-10-29

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cc-by-nc-nd (c) Sáez Fuertes, Laura et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/229693

Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life

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https://doi.org/10.1002/mnfr.202400377

Resum

The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn’s ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M-16 V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups’ plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune-related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup’s diarrhea caused by the RV infection by improving their immunity.

Matèries

Sistema immunitari, Malalties neonatals, Mortalitat infantil, Expressió gènica

Matèries (anglès)

Immune system, Neonatal diseases, Infant mortality, Gene expression

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Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))

Citació

SÁEZ FUERTES, Laura, et al. Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life. Molecular Nutrition & Food Research. 2024. Vol. 68, num. 22, pags. 2400377. ISSN 1613-4125. [consulted: 30 of May of 2026]. Available at: https://hdl.handle.net/2445/229693

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