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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/226282
Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function
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Objectives: Neuroimaging studies of dyskinetic cerebral palsy (CP) are scarce and the neuropathological underpinnings are not fully understood. We delineated the corticospinal tract (CST) and cortico-striatal-thalamocortical (CSTC) pathways with probabilistic tractography to assess their (1) integrity and (2) association with motor functioning in people with dyskinetic CP. Methods: Diffusion weighted magnetic resonance images were obtained for 33 individuals with dyskinetic CP and 33 controls. Fractional anisotropy (FA) and mean diffusivity (MD) for the CST and the CSTC pathways were compared between groups. Correlation analyses were performed between tensor metric values and motor function scores of participants with dyskinetic CP as assessed by the Gross Motor Function Classification System (GMFCS), the Bimanual Fine Motor Function (BFMF), and the Manual Ability Classification System (MACS). Results: White matter integrity in both the CST and the CSTC pathways was reduced in people with dyskinetic CP. The GMFCS, MACS and, less commonly, the BFMF were associated with FA and, particularly, MD in most portions of these pathways. Interpretation: The present study advances our understanding of the involvement of white matter microstructure in sensorimotor pathways and its relationship with motor impairment in people with dyskinetic CP. Our results are consistent with well-described relationships between upper limb function and white matter integrity in the CST and CSTC pathways in other forms of CP. This knowledge may ultimately help prognosis and therapeutic programmes.
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CALDÚ I FERRÚS, Xavier, REID, Lee b., PANNEK, Kerstin, FRIPP, Jurgen, BALLESTER PLANÉ, Júlia, LEIVA UREÑA, David, BOYD, Roslyn, PUEYO BENITO, Roser, LAPORTA-HOYOS, Olga. Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function. _Annals of Clinical and Translational Neurology_. 2024. Vol. 11, núm. 10, pàgs. 2609-2622. [consulta: 12 de febrer de 2026]. ISSN: 2328-9503. [Disponible a: https://hdl.handle.net/2445/226282]