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2021-06-11

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cc-by-nc (c) Meira, Fernanda et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184472

Impact of Inflammatory Response Modifiers on the Incidence of Hospital-Acquired Infections in Patients with COVID-19.

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https://doi.org/10.1007/s40121-021-00477-9

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The study aim was to assess the influence of inflammatory response modifiers, including anti-interleukin-6 (IL-6) biologics and corticosteroids, on the incidence of hospital-acquired infections in patients with coronavirus disease 2019 (COVID-19). METHODS: Case-control study performed at a university hospital from February 26 to May 26, 2020. Cases were defined as patients with COVID-19 who developed hospital-acquired infections. For each case, two controls were selected among patients without infections. Cases and controls were matched obeying three criteria in a hierarchical sequence: length of hospital stay up until the first infection; comorbidity; and need for Intensive care unit (ICU) admission. Conditional logistic regression analysis was used to estimate the association of exposures with being a case. RESULTS: A total of 71 cases and 142 controls were included. Independent predictors for acquiring a hospital infection were chronic liver disease [odds ratio (OR) 16.56, 95% CI 1.87-146.5, p = 0.012], morbid obesity (OR 6.11, 95% CI 1.06-35.4, p = 0.043), current or past smoking (OR 4.15, 95% CI 1.45-11.88, p = 0.008), exposure to hydroxychloroquine (OR 0.2, 95% CI 0.041-1, p = 0.053), and invasive mechanical ventilation (OR 61.5, 95% CI 11.08-341, p ≤ 0.0001). CONCLUSIONS: Inflammatory response modifiers had no influence on acquisition of nosocomial infections in admitted patients with COVID-19. Hospital-acquired infections primarily occurred in the critically ill and invasive mechanical ventilation was the main exposure conferring risk.

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COVID-19, SARS-CoV-2, Infeccions nosocomials

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COVID-19, SARS-CoV-2, Nosocomial infections

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MEIRA, Fernanda, MORENO GARCÍA, Estela, LINARES, Laura, MACAYA, Irene, TOMÉ, Adrià, HERNÁNDEZ-MENESES, Marta, ALBIACH, Laia, MORATA, Laura, LETONA GIMÉNEZ, Laura, BODRO, Marta, CÓZAR LLISTÓ, Alberto, CARDOZO ESPINOLA, Celia, CHUMBITA, Mariana, PITART, Cristina, AMBROSIONI, Juan, RICO, Verónica, AGÜERO, Daiana, PUERTA-ALCALDE, Pedro, GARCÍA POUTON, Nicole, MARCO, Francesc, GARCIA VIDAL, Carolina, SORIANO VILADOMIU, Alex, MARTÍNEZ, José antonio. Impact of Inflammatory Response Modifiers on the Incidence of Hospital-Acquired Infections in Patients with COVID-19.. _Infectious Diseases and Therapy_. 2021. Vol. 10, núm. 3, pàgs. 1407-1418. [consulta: 9 de gener de 2026]. ISSN: 2193-8229. [Disponible a: https://hdl.handle.net/2445/184472]

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