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2025-11-21

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cc-by (c) Poyatos, P. et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/226274

Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3- and 6-month post-infection

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https://doi.org/10.1016/j.isci.2025.113731

Resum

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant global morbidity since 2019. Long COVID, characterized by persistent symptoms after acute infection, may involve endothelial injury. We analyzed endothelial colony-forming cells (ECFCs) from post-COVID-19 patients at 3- and 6-month post-infection, comparing them with healthy controls and stratifying by prior pulmonary embolism (PE). Transcriptomic profiling identified differentially expressed genes (DEGs) associated with endothelial homeostasis, inflammation, oxidative stress, and thrombosis. Post-COVID ECFCs showed downregulation of NOS3, KLF2, ANGPT1, PIK3R3, GBX2, GDF6, SMAD6, SRC, and TGFB1, and upregulation of CASP1, CXCL5, IL12A, SOD2, TIMP3, and TLR2. Minimal differences were observed between 3 and 6-month samples. PE patients showed downregulation of thrombosis-related genes such as PTGS2 and ACKR3. These findings indicate sustained endothelial dysfunction and inflammation up to 6 months post-infection, highlighting the importance of long-term monitoring and potential therapeutic strategies to support vascular health in post-COVID-19 patients.

Matèries

Endoteli, Embòlia pulmonar, COVID-19

Matèries (anglès)

Endothelium, Pulmonary embolism, COVID-19

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citació

POYATOS DORADO, Paula, GRATACÒS-AURICH, Miquel, AGUILAR, Daniel, LUQUE, Neus, BONNIN VILAPLANA, Marc, EIZAGUIRRE, Saioa, CASCANTE I SERRATOSA, Marta, ORRIOLS MARTÍNEZ, Ramon, TURA-CEIDE, Olga. Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3- and 6-month post-infection. _iScience_. 2025. Vol. 28, núm. 11, pàgs. 1-12. [consulta: 28 de gener de 2026]. ISSN: 2589-0042. [Disponible a: https://hdl.handle.net/2445/226274]

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