Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/105633
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids.
Related resource
Subject (English)
Citation
Citation
SLEBE, Felipe, et al. FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth. Nature Communications. 2016. Vol. 7, num. 11199. [consulted: 7 of October of 2026]. Available at: https://hdl.handle.net/2445/105633