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2022-09-14

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cc-by (c) Diaba, Faïza et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/190124

Cytotoxic Assessment of 3,3-Dichloro-β-Lactams Prepared through Microwave-Assisted Benzylic C-H Activation from Benzyl-Tethered Trichloroacetamides Catalyzed by RuCl2(PPh3)3

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https://doi.org/10.3390/molecules27185975

Abstract

Natural and synthetic ß -lactam derivatives constitute an interesting class of compounds due to their diverse biological activity. Mostly used as antibiotics, they were also found to have antitubercular, anticancer and antidiabetic activities, among others. In this investigation, six new 3,3-dichloro-ß -lactams prepared in a previous work were evaluated for their hemolytic and cytotoxic properties. The results showed that the proposed compounds have non-hemolytic properties and exhibited an interesting cytotoxic activity toward squamous cell carcinoma (A431 cell line), which was highly dependent on the structure and concentration of these -lactams. Among the molecules tested, 2b was the most cytotoxic, with the lowest IC50 values (30-47 µg/mL) and a promising selectivity against the tumor cells compared with non-tumoral cells.

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Citotoxicitat per mediació cel·lular, Microones, Carcinògens

Subject (English)

Cell-mediated cytotoxicity, Microwaves, Carcinogens

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Bioquímica i Fisiologia)

Citation

DIABA, Faïza, SANDOR, Alexandra G. and MORÁN BADENAS, María del Carmen. Cytotoxic Assessment of 3,3-Dichloro-β-Lactams Prepared through Microwave-Assisted Benzylic C-H Activation from Benzyl-Tethered Trichloroacetamides Catalyzed by RuCl2(PPh3)3. Molecules. 2022. Vol. 27, num. 5975. ISSN 1420-3049. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/190124

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