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2017-05-04

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/192645

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates

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https://doi.org/10.1056/NEJMc1612804

Abstract

Atypical femoral fractures have been associated with long-term bisphosphonate treatment.1,2 However, the underlying mechanisms remain obscure. We studied three sisters who had atypical femoral fractures after receiving various oral bisphosphonates for 6 years. Two of the sisters had a single fracture (at the ages of 64 and 73 years), and one had bilateral fractures (one at the age of 60 years and the other at the age of 61 years). Given the low incidence of atypical femoral fractures in the general population (5.9 per 10,000 person-years),3 we hypothesized that these sisters might have an underlying genetic background that contributed to these fractures.

Subject

Mutació (Biologia), Fractures, Músculs

Subject (English)

Mutation (Biology), Fractures, Muscles

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citation

ROCA AYATS, Neus, et al. GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates. New England Journal of Medicine. 2017. Vol. 376, num. 18, pags. 1794-1795. ISSN 0028-4793. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/192645

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