El CRAI romandrà tancat del 24 de desembre de 2025 al 6 de gener de 2026. La validació de documents es reprendrà a partir del 7 de gener de 2026.
El CRAI permanecerá cerrado del 24 de diciembre de 2025 al 6 de enero de 2026. La validación de documentos se reanudará a partir del 7 de enero de 2026.
From 2025-12-24 to 2026-01-06, the CRAI remain closed and the documents will be validated from 2026-01-07.
 
Miniatura

Fitxers

885458.pdf (15.77 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2024-12-05

Llicència de publicació

cc-by (c) Brotons, P. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219086

Pneumococcal nasopharyngeal carriage in children and adults self-confined at home during a COVID-19 national lockdown.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1371/journal.pone.0315081

Resum

Background: Despite growing evidence of reduced invasive and non-invasive pneumococcal disease attributed to public health measures against the COVID-19 pandemic, the effect of these measures on pneumococcal carriage remains unclear. This study aimed to assess pneumococcal nasopharyngeal carriage among children and adults self-confined at home during the COVID-19 national lockdown in Spain while identifying predictors of pneumococcal carriage in children. Methods: Household study conducted across the metropolitan area of Barcelona (Spain) between April-June 2020. Nasopharyngeal samples were collected from young children and adults for real-time PCR pneumococcal lytA and wgz gene detection, quantification, and serotyping, as well as for detection of respiratory viruses. Results: Among 332 children (median age: 3.1 years [IQR: 1.9-4.0 years]; 59% male) and 278 adults (median age: 38.9 years [IQR: 36.1-41.3 years]; 64% female), pneumococcal carriage rates were 28.3% and 2.5%, respectively. Highly invasive serotypes 3, 7F/7A, and 19A were detected in 14.0% of samples from children carriers. Pneumococcal co-infections with respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and influenza virus (IV) were not identified in children. Attendance to kindergarten before the lockdown (aOR: 2.65; IQR: 1.57-4.47; p<0.001) and household crowding (aOR: 1.85; IQR: 1.09-3.15; p = 0.02) were independent risk factors for children's pneumococcal carriage. Conclusions: Pneumococcal carriage rate among quarantined children during a full COVID-19 lockdown was moderate and correlated with limited presence of highly invasive serotypes and absence of pneumococcal co-infections with RSV, hMPV, and IV. Pre-lockdown daycare and household crowding predisposed children to carriage.

Matèries

COVID-19, Pandèmia de COVID-19, 2020-, Salut pública, Infeccions per pneumococs

Matèries (anglès)

COVID-19, COVID-19 Pandemic, 2020-, Public health, Pneumococcal Infections

Citació

Col·leccions

Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (ISGlobal)

Citació

BROTONS, Pedro, CISNEROS, María, PÉREZ ARGÜELLO, Amaresh, HENARES, Desiree, LLUANSÍ, Aleix, FERNÁNDEZ DE SEVILLA ESTRACH, Mariona, CIRUELA, Pilar, BLANCO FUERTES, Miguel, LAUNES MONTAÑA, Cristian, JORDÁN GARCÍA, Iolanda, BASSAT ORELLANA, Quique, GARCÍA GARCÍA, Juan josé, MUÑOZ ALMAGRO, Carmen. Pneumococcal nasopharyngeal carriage in children and adults self-confined at home during a COVID-19 national lockdown.. _PLoS One_. 2024. Vol. 19, núm. 12, pàgs. e0315081. [consulta: 8 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/219086]

Exportar metadades

JSON - METS

Compartir registre