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2019-03-05

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/141947

Fibre-type-specific and Mitochondrial Biomarkers of Muscle Damage after Mountain Races

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https://doi.org/10.1055/a-0808-4692

Resum

Consequences of running mountain races on muscle damage were investigated by analysing serum muscle enzymes and fibre-type-specific sarcomere proteins. We studied 10 trained amateur and 6 highly trained runners who ran a 35 km and 55 km mountain trail race (MTR), respectively. Levels of creatine kinase (CK), CK-MB isoform (CK-MB), sarcomeric mitochondrial CK (sMtCK), transaminases (AST and ALT), cardiac troponin I (cTnI) and fast (FM) and slow myosin (SM) isoforms, were assessed before, 1 h, 24 h and 48 h after the beginning of MTR. Significant SM increases were found at 24 h in the 55 km group. Levels of CK, CK-MB, AST and cTnI were significantly elevated in both groups following MTR, but in the 55 km group they tended to stabilize in at 48 h. Using pooled data, time-independent serum peaks of SM and CK-MB were significantly correlated. Moreover, concentration of sMtCK was significantly elevated at 1 and 24 h after the race in the 35 km group. Although training volume could confer protection on the mitochondria, the increase in serum CK-MB and SM in the 55 km group might be related to damage to the contractile apparatus type I fibres. Competing in long-distance MTRs might be related to deeper type I muscle fibre damage, even in highly trained individuals.

Matèries

Marcadors bioquímics, Exercici, Fisiologia de l'exercici, Cèl·lules musculars

Matèries (anglès)

Biochemical markers, Exercise, Exercise physiology, Muscle cells

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Articles publicats en revistes (Biomedicina)

Citació

CARMONA DALMASES, Gerard, et al. Fibre-type-specific and Mitochondrial Biomarkers of Muscle Damage after Mountain Races. International Journal of Sports Medicine. 2019. Vol. 40, num. 4, pags. 253-262. ISSN 0172-4622. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/141947

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