Miniatura

Fitxers

717964.pdf (1.5 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2022-01-10

Llicència de publicació

cc-by-nc-nd (c) King Saud University, 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183715

Synthesis of pyrazolo-enaminones, bipyrazoles and pyrazolopyrimidines and evaluation of antioxidant and antimicrobial properties

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.arabjc.2021.103527

Resum

A novel pyrazolo-enaminones, bipyrazoles and bipyrazolopyridines from 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)butane-1,3-dione and 4-methyl-2-phenyl-2H-pyrazolo[3,4-b]pyridine-3,6(3aH,7H)-dione have been synthesized by assisted heating with microwave radiation without any catalyst. The pyridine and pyrazole ring formation has been developed from easily accessible enamino keto esters by formylation followed by intramolecular cyclization. The general applicability for the synthesis of the important pyrazolo-enaminones, bipyrazoles and pyrazolo-pyridines heterocycles was attributed to simplicity of operation, synthesis without catalyst, energy efficiency (shorter reaction time under microwave irradiation), good yields, more environmentally friendly and more cost-effective procedure. The antioxidant activity of new heterocyclic compounds was evaluated by free radical scavenging by DPPH assay. Several of these compounds showed good activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria.

Matèries

Síntesi orgànica, Antioxidants, Agents antiinfecciosos

Matèries (anglès)

Organic synthesis, Antioxidants, Anti-infective agents

Citació

Col·leccions

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citació

AKHRAMEZ, Soufiane, OUMESSAOUD, Asmaa, HIBOT, Achraf, TALBI, Soumaya, HAMRI, Salha, KETATNI, El mostafa, OUCHETTO, Hajiba, HAFID, Abderrafia, AYAD, Houda, EL ABBADI, Noureddine, ZANANE, Chorouk, LATRACHE, Hassan, KHOUILI, Mostafa, PUJOL DILMÉ, M. dolors. Synthesis of pyrazolo-enaminones, bipyrazoles and pyrazolopyrimidines and evaluation of antioxidant and antimicrobial properties. _Arabian Journal of Chemistry_. 2022. Vol. 15, núm. 103527. [consulta: 9 de gener de 2026]. ISSN: 1878-5352. [Disponible a: https://hdl.handle.net/2445/183715]

Exportar metadades

JSON - METS

Compartir registre