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2025-03-06

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cc-by (c) Barrantes-Vidal, N. et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/228863

Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life.

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Recurs relacionat

https://doi.org/10.1093/schbul/sbad162

Resum

Background and Hypothesis: Consistent with diathesis-stress models, psychosis research has focused on geneticmoderation of adverse environmental exposures. In con-trast, the Differential Susceptibility (DS) model suggeststhat the same genetic variants that increase risk-inducingeffects of adverse experiences also enhance beneficial ef-fects from positive experiences. This study examinedwhether individuals with high genetic susceptibility to theenvironment showed differential psychotic-like and affec-tive reactivity in response to positive and negative events indaily life. Study Design: Experience sampling methodologyassessed context (positive and stressful) and momentarylevels of paranoia, psychotic-like experiences (PLE), andpositive (PA) and negative affect (NA) in 217 non-clinicaladults oversampled for schizotypy. Linear mixed modelsexamined whether Polygenic Risk Scores of EnvironmentalSensitivity (PRS-ES) moderated the impact of current con-text on subsequent experiences. Study Results: PRS-ESmoderated positive, but not stressful, context on subsequentlevels of momentary paranoia, NA, and PA, but not PLE.Genetic and environmental (G × E) interactions indicateddiathesis-stress at lower thresholds of PRS-ES, but a DSmodel at the highest threshold of the PRS-ES. Participantswith elevated PRS-ES showed increased paranoia and NAand decreased PA in subsequent assessments when re-porting low levels of positive situations, but also decreasedparanoia and NA and increased PA when rating contextsas positive. Conclusions: Findings support the influence ofgenetic sensitivity to the environment on psychotic-like andaffective reactivity in daily life, particularly in response topositive contexts. This highlights the transdiagnostic pro-tective role of positive experiences and informs ecologicalmomentary interventions.

Matèries

Psicologia, Genètica humana, Trastorns afectius

Matèries (anglès)

Psychology, Human genetics, Affective disorders

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Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

Citació

BARRANTES VIDAL, Neus, et al. Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life. Schizophrenia Bulletin. 2025. Vol. 51, num. 74-84. ISSN 0586-7614. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/228863

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