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2016-06-29

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cc-by (c) Santacana, Marti et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/112016

Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment.

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https://doi.org/10.1371/journal.pone.0158224

Resum

BACKGROUND: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards 'personalized medicine'. Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). METHOD: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. RESULTS: We identified two response trajectories ('high response' and 'low response'), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. CONCLUSIONS: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches.

Matèries

Ansietat, Trastorns de pànic, Maltractament infantil, Genètica humana, Polimorfisme genètic

Matèries (anglès)

Anxiety, Panic disorders, Child abuse, Human genetics, Genetic polymorphisms

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Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

Citació

SANTACANA, Marti, et al. Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment. PLoS One. 2016. Vol. 11, núm. 6, pàgs. e0158224. ISSN 1932-6203. [consulta: 8 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/112016

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