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724351.pdf (1.83 MB)

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2022

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cc by-nc-nd (c) Gabriel Mercadal-Orfila, et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/189351

HIV-positive women have higher prevalence of comorbidites and anticholinergic burden. Assessment of the HIV positive population from Menorca (Balearic Islands)

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Recurs relacionat

https://doi.org/10.1080/09540121.2022.2067518

Resum

Currently, the management of comorbidities and polypharmacy in HIV-infected patients requires a coordinated action, with special focus on gender differences. Observational, cross-sectional study was conducted to study the HIV population from Menorca (Illes Balears). Adult HIV-positive individuals on antiretroviral treatment attending the pharmacy service from Hospital Mateu Orfila (Menorca) were included. In a single visit, demographical and clinical characteristics, comorbidities and cotreatments were collected. Anticholinergic burden (Drug Burden Index, DBI), drug-to-drug interactions (BOT PLUS database) and symptoms associated with HIV treatment (HIV-SI index) were assessed. A total of 223 patients were included, 68.2% men, with a median age of 53.00 (44.50-58.00) years, median BMI of 24.07, 47.73% smokers and 9.90% drug consumers. Women had more advanced stages of the disease and significantly more symptoms (cough and anxiety) versus men (p = .033 and p = .048, respectively). Moreover higher exposures to anticholinergic drugs (DBI 0.51 vs. 0.27) were reported, together with more frequency of drug-to-drug interactions (57.7% vs. 37.5%; p = .005) that increased with age. Red interactions were more frequently reported in PI (2.69%), NNRTIs (1.92%) and booster drugs (1.92%). These results support the need to implement specific measures for the management of HIV-infected women and tools to assess polypharmacy and risk of drug-to-drug interactions. Keywords: HIV infection; anticholinergic burden; anxiety; comorbidities; drug-to-drug interactions; women.

Matèries

Infeccions per VIH, VIH (Virus), Dones

Matèries (anglès)

HIV infections, HIV (Viruses), Women

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Col·leccions

Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

Citació

MERCADAL-ORFILA, Gabriel, et al. HIV-positive women have higher prevalence of comorbidites and anticholinergic burden. Assessment of the HIV positive population from Menorca (Balearic Islands). Aids Care-Psychological and Socio-Medical Aspects of Aids/Hiv. 2022. Vol. 1-10. ISSN 0954-0121. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/189351

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