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2023-08-12

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What are the current trends in G protein-coupled receptor targeted drug discovery?

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https://doi.org/10.1080/17460441.2023.2216014

Resum

G protein-coupled receptors (GPCRs) constitute a superfamily of membrane proteins which have in common the presence of 7 transmembrane α-helices linked by several intra- and extracellular loops. This particular structure is important for extracellular stimulus recognition through the amino acids forming the extracellular loops (class B, C and F of GPCRs) or by the transmembrane α-helices (class A and B of GPCRs). Their structure is also essential for signal transduction via intracellular proteins (G proteins, arrestins and kinases – GRKs-) [Citation1]. These proteins are attached to the intracellular loops and/or to the intracellular regions of the α-helices of the GPCRs, even when they are not activated by extracellular ligands or drugs.

Matèries

Proteïnes G, Enzims al·lostèrics

Matèries (anglès)

G Proteins, Allosteric enzymes

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

CASADÓ, Vicent and CASADÓ ANGUERA, Verònica. What are the current trends in G protein-coupled receptor targeted drug discovery?. Expert Opinion on Drug Discovery. 2023. Vol. 18, num. 8, pags. 815-820. ISSN 1746-0441. [consulted: 23 of May of 2026]. Available at: https://hdl.handle.net/2445/225834

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