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1991-04

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cc-by-nc-nd (c) American Diabetes Association, 1991
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/134640

Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture

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https://doi.org/10.2337/diab.40.4.462

Abstract

In primary culture of adult rat hepatocytes, vanadate in the presence of glucose stimulates the expression of the liver (L-type) pyruvate kinase gene. Glucose by itself was inactive, and vanadate, like insulin, was also inefficient in the absence of glucose. Similar results were obtained on glucokinase gene expression. An analogue of cAMP, 8-(4-chlorophenylthio)-cAMP, inhibited the production of L-type pyruvate kinase and glucokinase mRNAs in the presence of glucose plus vanadate.

Subject

Micro RNAs, Isoenzims, Genètica, Fetge, Enzimologia, Biosíntesi, Farmacologia

Subject (English)

MicroRNAs, Isoenzymes, Genetics, Liver, Enzymology, Biosynthesis, Pharmacology

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Articles publicats en revistes (Ciències Fisiològiques)

Citation

MIRALPEIX, Montserrat, et al. Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture. Diabetes. 1991. Vol. 40, num. 4, pags. 462-464. ISSN 0012-1797. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/134640

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