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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/128081
Slamf6 negatively regulates autoimmunity
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The nine SLAM family (Slamf) receptors are positive or negative regulators of adaptive and innate immune responses, and of several autoimmune diseases. Here we report that the transfer of Slamf6-/- B6 CD4+ T cells into co-isogenic bm12 mice causes SLE-like autoimmunity with elevated levels of autoantibodies. In addition, significantly higher percentages of Tfh cells and IFN-γ-producing CD4+ cells, as well as GC B cells were observed. Interestingly, the expression of the Slamf6-H1 isoform in Slamf6-/- CD4+ T cells did not induce this lupus-like phenotype. By contrast, Slamf1-/- or Slamf5-/- CD4+ T cells caused the same pathology as WT CD4+ T cells. As the transfer of Slamf [1+6]-/- or Slamf [1+5+6]-/- CD4+ T cells induced WT levels of autoantibodies, the presence of Slamf1 was requisite for the induction of increased levels of autoantibodies by Slamf6-/- CD4+ T cells. We conclude that Slamf6 functions as an inhibitory receptor that controls autoimmune responses.
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WANG, Ninghai, KESZEI, Marton, HALIBOZEK, Peter j., YIGIT, Burcu, ENGEL ROCAMORA, Pablo, TERHORST, Cox. Slamf6 negatively regulates autoimmunity. _Clinical Immunology_. 2016. Vol. 173, núm. 19-26. [consulta: 21 de gener de 2026]. ISSN: 1521-6616. [Disponible a: https://hdl.handle.net/2445/128081]