Miniatura

Fitxers

711906.pdf (9.18 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2021-03-06

Llicència de publicació

cc-by-nc-nd (c) Gabasa Ferràndez, Marta et al, 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/185223

MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.canlet.2021.01.028

Resum

Large cell carcinoma (LCC) is a rare and aggressive lung cancer subtype with poor prognosis and no targeted therapies. Tumor-associated fibroblasts (TAFs) derived from LCC tumors exhibit premature senescence, and coculture of pulmonary fibroblasts with LCC cell lines selectively induces fibroblast senescence, which in turn drives LCC cell growth and invasion. Here we identify MMP1 as overexpressed specifically in LCC cell lines, and we show that expression of MMP1 by LCC cells is necessary for induction of fibroblast senescence and consequent tumor promotion in both cell culture and mouse models. We also show that MMP1, in combination with TGF-β1, is sufficient to induce fibroblast senescence and consequent LCC promotion. Furthermore, we implicate PAR-1 and oxidative stress in MMP1/TGF-β1-induced TAF senescence. Our results establish an entirely new role for MMP1 in cancer, and support a novel therapeutic strategy in LCC based on targeting senescent TAFs.

Matèries

Càncer de pulmó, Tumors, Fibroblasts, Metal·loproteïnases

Matèries (anglès)

Lung cancer, Tumors, Fibroblasts, Metalloproteinases

Citació

Col·leccions

Articles publicats en revistes (Biomedicina)
<b>Publicacions de projectes de recerca finançats per la UE</b>
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

GABASA FERRÀNDEZ, Marta, RADISKY, Evette s, IKEMORI, Rafael, BERTOLINI, Giulia, ARSHAKYAN, Marselina, HOCKLA, Alexandra, DUCH, Paula, RONDINONE, Ornella, LLORENTE, Alejandro, MAQUEDA, Maria, DÁVALOS, Albert, GAVILÁN, Elena, PERERA LLUNA, Alexandre, RAMÍREZ RUZ, J. (josé), GASCÓN, Pere, REGUART, Noemí, ROZ, Luca, RADISKY, Derek c, ALCARAZ CASADEMUNT, Jordi. MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence. _Cancer Letters_. 2021. Vol. 507, núm. 1-12. [consulta: 10 de gener de 2026]. ISSN: 0304-3835. [Disponible a: https://hdl.handle.net/2445/185223]

Exportar metadades

JSON - METS

Compartir registre