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Zumel-Marne2020_Article_ClinicalPresentationOfYoungPeo.pdf (810.05 KB)

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2020-03-03

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cc by (c) Springer Verlag , 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/152321

Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study

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http://dx.doi.org/10.1007/s11060-020-03437-4

Abstract

Introduction: We used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). Methods: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. Results: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and ‘non-neuroepithelial’ tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/ vomiting was the only combination of symptoms that exceeded a cutof of 50%, with a joint occurrence of 67%. Overall, the median time from frst symptom to diagnosis was 1.42 months (IQR0.53–4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. Conclusions: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identifed, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.

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Tumors cerebrals, Diagnòstic

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Brain tumors, Diagnosis

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Articles publicats en revistes (ISGlobal)

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ZUMEL MARNE, Angela, et al. Clinical presentation of young people (10-24 years old) with
                brain tumors: results from the international MOBI-Kids study. Journal of Neuro-Oncology. 2020. ISSN 0167-594X. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/152321

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