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255598.pdf (20.68 MB)

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2023-03

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cc-by-nc (c) Ballasch, Ivan et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/207664

Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration

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Recurs relacionat

https://doi.org/10.1016/j.bbi.2023.01.016

Resum

Using genetic tools, here we describe that Ikzf1 is specifically expressed in the adult microglia in brain regions such as cortex and hippocampus. By characterizing the Ikzf1 deficient mice, we observed that these mice displayed spatial learning deficits, impaired hippocampal CA3-CA1 long-term potentiation, and decreased spine density in pyramidal neurons of the CA1, which correlates with an increased expression of synaptic markers within microglia. Additionally, these Ikzf1 deficient microglia exhibited a severe abnormal morphology in the hippocampus, which is accompanied by astrogliosis, an aberrant composition of the inflammasome, and an altered expression of disease-associated microglia molecules. Interestingly, the lack of Ikzf1 induced changes on histone 3 acetylation and methylation levels in the hippocampus. Since the lack of Ikzf1 in mice appears to induce the internalization of synaptic markers within microglia, and severe gliosis we then analyzed hippocampal Ikzf1 levels in several models of neurological disorders. Ikzf1 levels were increased in the hippocampus of these neurological models, as well as in postmortem hippocampal samples from Alzheimer’s disease patients. Finally, over-expressing Ikzf1 in cultured microglia made these cells hyporeactive upon treatment with lipopolysaccharide, and less phagocytic compared to control microglia. Altogether, these results suggest that altered Ikzf1 levels in the adult hippocampus are sufficient to induce synaptic plasticity and memory deficits via altering microglial state and function.

Matèries

Hipocamp (Cervell), Malalties neurodegeneratives, Micròglia, Memòria, Aprenentatge, Escorça cerebral

Matèries (anglès)

Hippocampus (Brain), Neurodegenerative Diseases, Microglia, Memory, Learning, Cerebral cortex

Citació

Col·leccions

Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

BALLASCH, Iván, et al. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain. Behavior. Vol.  and Immunity, num. 2023, pags. 109. ISSN 0889-1591. [consulted: 23 of August of 2026]. Available at: https://hdl.handle.net/2445/207664

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