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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173199
Data on the effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with mild COVID-19
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The trial was conducted in the Pamplona metropolitan area (Navarra, Spain). Patients were enrolled between July 31, 2020 and September 11, 2020 and randomized in a 1:1 ratio to ivermectin (400 mcg/kg) single oral dose or placebo. Assessments on enrollment and at days 4, 7, 14, 21 and 28 post treatment included: general symptoms report, physical examination and adverse events. All patients were asked to complete a daily online diary of symptoms from day 1 to 28 post treatment. On enrollment, as well as on days 7 and 14 blood samples were obtained to assess full blood count, C reactive protein, procalcitonin, ferritin, creatinine phosphokinase, lactic dehydrogenase, troponin T, D dimer, IL-6, and renal function. Viral loads were calculated at enrollment and on days 4, 7, 14 and 21 post treatment based on a nasopharyngeal swab for SARS-CoV-2 PCR (for genes N and E). A semi-quantitative serology for IgG against SARS-CoV-2 was done on samples from all patients on day 21 post-treatment.
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Dades primàries associades a l'article publicat a EClinicalMedicine, vol. 32 [https://doi.org./10.1016/j.eclinm.2020.100720]
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CHACCOUR, Carlos, CASELLAS, Aina, BLANCO-DI MATTEO, Andrés, PINEDA, Iñigo, FERNÁNDEZ MONTERO, Alejandro, RUIZ CASTILLO, Paula, RICHARDSON, Mary-ann, RODRÍGUEZ MATEOS, Mariano, JORDÁN IBORRA, Carlota, BREW, Joe, CARMONA TORRE, Francisco, GIRÁLDEZ, Miriam, LASO, Ester, DOBAÑO, Carlota, MONCUNILL PIÑAS, Gemma, YUSTE, José r., POZO, José luis del, RABINOVICH, Regina, SCHÖNING, Verena, HAMMANN, Felix, REINA, Gabriel, SADABA, Belen, FERNÁNDEZ ALONSO, Miriam. Data on the effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with mild COVID-19. [consulta: 25 de novembre de 2025]. [Disponible a: https://hdl.handle.net/2445/173199]