El CRAI romandrà tancat del 24 de desembre de 2025 al 6 de gener de 2026. La validació de documents es reprendrà a partir del 7 de gener de 2026.
El CRAI permanecerá cerrado del 24 de diciembre de 2025 al 6 de enero de 2026. La validación de documentos se reanudará a partir del 7 de enero de 2026.
From 2025-12-24 to 2026-01-06, the CRAI remain closed and the documents will be validated from 2026-01-07.
 
Miniatura

Fitxers

681426.pdf (905.37 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2018-08-30

Llicència de publicació

cc-by-nc-nd (c) Cabana-Domínguez, Judit et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/124445

MIR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in adopaminergic cell model and may contribute to cocaine dependence

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/s41398-018-0224-5

Resum

Cocaine is one of the most used psychostimulant drugs worldwide. MicroRNAs are post-transcriptional regulators of gene expression that are highly expressed in brain, and several studies have shown that cocaine can alter their expression. In a previous study, we identified several protein-coding genes that are differentially expressed in a dopaminergic neuron-like model after an acute exposure to cocaine. Now, we used the prediction tool WebGestalt to identify miRNA molecules potentially involved in the regulation of these genes. Using the same cellular model, we found that seven of these miRNAs are down-regulated by cocaine: miR-124-3p, miR-124-5p, miR-137, miR-101-3p, miR-9-5p, miR-369-3p and miR-153-3p, the last three not previously related to cocaine. Furthermore, we found that three of the miRNA genes that are differentially expressed in our model (hsa-miR-9-1, hsa-miR-153-1 and hsa-miR-124-3) are nominally associated with cocaine dependence in a case-control study (2,085 cases and 4,293 controls). In summary, we highlighted novel miRNAs that may be involved in those cocaine-induced changes of gene expression that underlie addiction. Moreover, we identified genetic variants that contribute to cocaine dependence in three of these miRNA genes, supporting the idea that genes differentially expressed under cocaine may play an important role in the susceptibility to cocaine dependence.

Matèries

Cocaïna, Drogoaddicció

Matèries (anglès)

Cocaine, Drug addiction

Citació

Col·leccions

Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citació

CABANA DOMÍNGUEZ, Judit, ARENAS SOLÀ, Concepción, CORMAND RIFÀ, Bru, FERNÀNDEZ CASTILLO, Noèlia. MIR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in adopaminergic cell model and may contribute to cocaine dependence. _Translational Psychiatry_. 2018. Vol. 8. [consulta: 5 de gener de 2026]. ISSN: 2158-3188. [Disponible a: https://hdl.handle.net/2445/124445]

Exportar metadades

JSON - METS

Compartir registre