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2013-04-26

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/108593

Regulation of N-Myc downstream regulated gene 2 by bile acids

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https://doi.org/10.1016/j.bbrc.2013.03.058

Abstract

Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes. Knockdown of FXR abolished the induction by CDCA, whereas overexpre ssion of a constitutively active form of FXR increased NDRG2 expression. A FXR-response element was identified within intronic regions of human and murine genes. Moreover, mice given GW4064 exhib it an increase of Ndrg2 expression in liver and kidney, where both NDRG2 and FXR are enriched. The identification of NDRG2 as a bile acid regulated gene may provide novel knowledge toward the understanding of NDRG2 physiological function and the link between metabolism and cancer.

Subject

Àcids biliars, Receptors nuclears (Bioquímica), Càncer, Metabolisme, Ronyó, Regulació genètica, Proteïnes

Subject (English)

Bile acids, Nuclear receptors (Biochemistry), Cancer, Metabolism, Kidney, Genetic regulation, Proteins

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Articles publicats en revistes (Bioquímica i Fisiologia)

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LANGHI, Cédric, et al. Regulation of N-Myc downstream regulated gene 2 by bile acids. Biochemical and Biophysical Research Communications. 2013. Vol. 434, num. 1, pags. 102-109. ISSN 0006-291X. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/108593

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