Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/193594
Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression
Títol de la revista
Director/Tutor
Contribució addicional
ISSN de la revista
Títol del volum
Resum
Planarians are flatworms capable of whole-body regeneration, able to regrow any missing body part after injury or amputation. The extraordinary regenerative capacity of planarians is based upon the presence in the adult of a large population of somatic pluripotent stem cells. These cells, called neoblasts, offer a unique system to study the process of stem cell specification and differentiation in vivo. In recent years, FACS-based isolation of neoblasts, RNAi functional analyses as well as high-throughput approaches such as single-cell sequencing have allowed a rapid progress in our understanding of many different aspects of neoblast biology. Here, we summarize our current knowledge on the molecular signatures that define planarian neoblasts heterogeneity, which includes a percentage of truly pluripotent stem cells, and guide the commitment of pluripotent neoblasts into lineage-specific progenitor cells, as well as their differentiation into specific planarian cell types.
Recurs relacionat
Matèries
Matèries (anglès)
Citació
Citació
MOLINA JIMÉNEZ, M. Dolores and CEBRIÀ SÁNCHEZ, Francesc. Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression. Biomolecules. 2021. Vol. 11, num. 10, pags. 1532. ISSN 2218-273X. [consulted: 31 of October of 2026]. Available at: https://hdl.handle.net/2445/193594