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2026-07-17

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cc-by-nc-nd (c) Tirira, Paola et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/231153

Evaluating the stability and efficiency of Fe(III)-DTPA complex for prednisolone degradation by solar photoelectro-Fenton process at neutral pH

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Recurs relacionat

https://doi.org/10.1016/j.seppur.2026.139404

Resum

The stability of the Fe(III)-DTPA complex for its use as a promising homogeneous catalyst to solve the pH bottleneck in solar photoelectro-Fenton (SPEF) process was evaluated for the first time. Viability depends on its resistance to photodegradation and attack by reactive oxygen species; ideally, it should allow sufficient release of free iron catalyst while preserving ligand stability to prevent iron precipitation. Here, Fe(III)-to-ligand molar ratio was first optimized to ensure complete chelation within a wide pH range, as well as high photostability against UVA and sunlight and resistance to •OH attack. Results showed that Fe(III)-DTPA complex at ratios of 1:1 and 1:2 remained stable at pH 3–9 for at least 180 min. Notably, the 1:2 complex exhibited superior photostability and oxidative resistance during SPEF treatment, minimizing the iron precipitation. As a proof of concept, removal of the glucocorticoid prednisolone (PREDN) by SPEF at pH 7 was investigated. Complete degradation of 0.055 mM PREDN in 50 mM Na2SO4 medium containing 0.05 mM Fe(III)-DTPA (1:2) was achieved after 90 min at 30 mA cm−2. Although 95% of the complex was also degraded, the organic species derived from iron complex maintained a significant percentage of soluble iron (> 40%). Additionally, phytotoxicity and QSAR tests revealed that an initially pronounced toxicity due to by-products generated from DTPA and PREDN resolved into a non-toxic mixture with enhanced biodegradability. Therefore, Fe(III)-DTPA complex (1:2) can be considered a sustainable catalyst for SPEF treatment of drugs at circumneutral pH, combining acceptable operational stability and environmental safety.

Matèries

Electrogeneració d'aigua oxigenada, Glucocorticoides, Tractament d'aigua, Reacció de Fenton, Agent quelant

Matèries (anglès)

Hydrogen peroxide electrogeneration, Glucocorticoids, water treatment, Fenton's reaction, Chelating agent

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Articles publicats en revistes (Ciència dels Materials i Química Física)

Citació

TIRIRA, Paola, et al. Evaluating the stability and efficiency of Fe(III)-DTPA complex for prednisolone degradation by solar photoelectro-Fenton process at neutral pH. Separation and Purification Technology. 2026. Vol. 411, num. 1-12. ISSN 1383-5866. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/231153

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